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Cannabidiol (CBD) Oil Effects and Potential Benefits

By Dan Putnam May 07, 2017 0 comments

Cannabidiol (CBD) is the major non-psychoactive compound found in the cannabis plants marijuana and hemp. CBD does not cause a high in users, and has the ability to counteract some of the negative effects of tetrahydrocannabinol (THC). Numerous studies have been done that investigates the medicinal or therapeutic benefits to be had from CBD, and many shows promise in demonstrating that CBD has inflammatory, anticonvulsant, anti-oxidant, anti-emetic, anxiolytic and antipsychotic properties. Research has shown that CBD has the potential to treat numerous health conditions, such as, epilepsy, pain and inflammation, vomiting and nausea, anxiety, and cancer, among others. While the greatest area of interest for researchers appear to be the neuroprotective potential of CBD, which presently is the focus of preclinical investigations of different neurodegenerative disorders, the benefits of CBD seems far-reaching with each new scientific finding.

Relieves Nausea and Vomiting

Cannabis has long been used to suppress nausea and vomiting from a number of causes, but today, the science is providing evidence to firmly establish this potential. Research in the form of animal models has demonstrated that both THC and CBD can aid in minimizing nausea and vomiting by way of indirect activation of somatodendritic 5-HT (1A) autoreceptors in the dorsal raphe nucleus (DRN). Chemotherapy-induced vomiting, while is managed well with prescription medication, nausea continues to be a difficult symptom to control, and this is where CBD could prove quite useful. According to a 2012 study published in the British Journal of Pharmacology, which examined the anti-nausea and antiemetic effects of CBD in a rat model, researchers conclude that CBD suppresses nausea and vomiting within a limited dose range.

May Treat Epilepsy/Seizures

Research indicates that rare genetic disorders such as Dravet syndrome, which is a chronic seizure disorder caused by dysfunction in the brain, could be treated with CBD. GW Pharmaceuticals recently conducted clinical trials of their CBD product Epidiolex, which supports the findings of animals that point to the anti-seizure effects of CBD through their CBD extract called Epidiolex, which is 98% oil-based CBD. In March of 2016, the results of a Phase 3 randomized study of 120 Dravet syndrome patients, divided into two groups, Epidiolex 20mg/kg/day (n=61) and placebo (n=59), indicated that Epidiolex caused a significant reduction in convulsive seizures by 39% over a period of 4 weeks, compared to the placebo groups 13%.

Helps to Fight Cancer

More and more scientific studies are demonstrating that CBD could aid in fighting cancer, including breast, prostate, and brain cancers, by exerting antiproliferative and pro-apoptotic effects that inhibit cancer cell growth and migration from the point of origin to other parts of the body. Hemp oil with THC has been implicated in its ability to stop tumor growth. A 2013 study that investigated the effects of CBD on tumors generated in athymic mice, and researchers discovered that CBD reduced prostate cell proliferation, providing the basis for new therapies against prostate cancer.  These findings support the case for hemp CBD oil as a potentially viable cancer treatment medicine.

Relieves Pain and Inflammation

One of the most frequently mentioned benefits of CBD is its role as a natural pain reliever. Scientific evidence shows that CBD may inhibit neuronal transmission in pain pathways. According to a study published in the Journal of Experimental Medicine in 2012, researchers found that CBD diminished chronic inflammatory and neuropathic pain by targeting glycine receptors (GlyRs).  Research suggests that CBD could offer therapeutic benefits in relieving pain and inflammation associated with various conditions.

Lessens Anxiety

Cannabidiol (CBD) has been shown to have strong anxiolytic (anti-anxiety) effects as demonstrated in both animal and human studies. In a study published in 2011, Brazilian researchers conducted a small double-blind study, revealing that CBD could effectively reduce anxiety in patients with generalized social anxiety. Patients were orally administered 400 mg of CBD or placebo, and the results showed a dramatic decrease in social anxiety, a decrease that is associated with the impact that CBD could have on the activity in limbic and paralimbic areas of the brain. 

The science behind CBD is constantly expanding, demonstrating that many researchers are considering its potential as an alternative form of treatment for many conditions. While many studies regarding CBD are relatively new, the expanding data on the issue is a testament to the degree of interest that scientists have in the non-psychoactive cannabis compound CBD. As an agent that has the potential to ameliorate pain and inflammation, anxiety, epilepsy, cancer cell growth and migration, along with nausea and vomiting, this is just the tip of the iceberg, and much more research is warranted to validate the findings of earlier studies.

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